Analysis of red cell distribution width in patients presented with interstitial lung disease

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Jiss Ann Francis


Background: Redcell distribution width (RDW) is a prognostic tool of different clinical conditions and a powerful predictor of mortality in elder adults. Increased RDW values were related to underlying chronic inflammation including interstitial lung disease(ILD). RDW as a biomarker to assess the severity of disease in ILD patients was reported. This study was aimed to evaluatethe change in RDW in ILD patients in late stages of the disease.
Methods:A retrospective observational study was conducted among patients who died with ILD. Values of RDW during the later stages of disease (close to and 2 months beforedeath)werecollected from medical records. Variations of RDW in patients with or without smoking habits, occupational exposures, and types of ILD were also studied.Data were statistically analysed.
Results: Forty-two patients died with ILD included. The value of RDW at 2 months before death was 15.4 ±1.8, whereas the valueclose to death was 16.1 ±2.4(p=0.030). The change in RDW values during late stages of ILD is significant. There was no association between RDW value 2 months before death with smoking history(p=0.112) or occupation(p=0.119) or types of ILD(P=0.121). But 86% of people with the smoking history presented with abnormal
RDW value (>14.5%) at the time of their first presentation itself.No variation in RDW was found among patients with history of smoking status, occupational exposures, or types of ILD
Conclusion: Increase in RDW was associated with later stages of ILD. Change in RDW value in later stages of can be used as a biomarker for poor survival.

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Jiss Ann Francis

Amala Institute of Medical Sciences, Thrissur-680 555,
Kerala, India